Table of contents
I. Web Base Meeting to Discuss Solution to Overcome the Problem of Endosomal Escape for shRNAs/RNAi
II. NIDA Request for Applications (RFAs)
III. NIDA Program Announcements (PAs)
IV. NIDA Request for Information
I. Web Based Meeting to Discuss Solutions to Overcome the Problem of Endosomal Escape for shRNAs/RNAi
The purpose of this web-based meeting is to identify solutions to overcome the problem of endosomal escape for shRNA targeted therapies. shRNA, small hairpin RNA used to silence the expression of a selected gene has great promise as a therapeutic strategic to modify disease processes. However, a major roadblock to using shRNA or RNAi as a therapeutic strategy is the problem of endosomal escape. Current technology permits the targeting of shRNAs to specific cell types via recognition of cell surface molecules or receptors. The shRNA/ligand complex is then internalized into the endosome by endocytosis. Frequently, the shRNA fails to escape the endosome to find its target mRNA to block translation. If you are interested in participating and giving a presentation in this web based conference, please contact Dr. Jonathan D. Pollock, Chief, Genetics and Molecular Neurobiology Branch, National Institute on Drug Abuse, jpollock@mail.nih.gov, 301-435-1309. Please respond by Friday, February 25, 2011. Date, time, and instructions to join the meeting will follow.
II. Request for Applications
· Pre-Application for the 2011 NIDA Translational Avant-Garde Award for Medication Development for Diseases of Addiction (X02)
(PAR-11-102)
National Institute on Drug Abuse
Application Receipt Date(s): March 17, 2011, by 5:00 PM local time of applicant organization.
http://grants.nih.gov/grants/guide/pa-files/PAR-11-102.html
· New Molecular Entities to Treat Substance Use Disorders (R01
(RFA-DA-12-001)
National Institute on Drug Abuse
Application Due Date(s) March 17, 2011, by 5:00 PM local time of applicant organization.
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-12-001.html
· Predictive Animal Models for Smoking Cessation Medications (U54)
(RFA-DA-11-014)
National Institute on Drug Abuse
Application Receipt Date(s): March 31, 2011
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-014.html
· Exploring Human Induced Pluripotent Stem Cells for Substance Abuse Research (R21)
RFA-DA-11-012
National Institute on Drug Abuse
Application Due Date(s) March 31, 2011, by 5:00 PM local time of applicant organization.
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-012.html
· The Placebo Effect: Mechanisms and Methodology (R01)
RFA-12-003
National Institute on Drug Abuse (NIDA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Center for Complementary and Alternative Medicine (NCCAM)
Application Receipt Date: May 24, 2011, by 5:00 PM local time of applicant organization.
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-12-003.html
· The Placebo Effect: Mechanisms and Methodology (R21)
RFA-12-004
National Institute on Drug Abuse (NIDA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Center for Complementary and Alternative Medicine (NCCAM)
Application Receipt Date: May 24, 2011, by 5:00 PM local time of applicant organization
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-12-004.html
· Grand Opportunity in Medications Development for Substance-Related Disorders (U01)
(PAR-11-109)
National Institute on Drug Abuse
Application Receipt/Submission Date(s): May 26, 2011, August 26, 2011, March 27, 2012, July 27, 2012, March 27, 2013, July 26, 2013 AIDS: August 14, 2011, November 8, 2011, March 27, 2012, August 14, 2012, March 27, 2013, August 14, 2013
http://grants.nih.gov/grants/guide/pa-files/PAR-11-109.html
· 2011 NIDA Translational Avant-Garde Award for Medication Development for Diseases of Addiction (DP1)
RFA-DA-11-009
National Institute on Drug Abuse
Application Due Date(s) June 27, 2011, by 5:00 PM local time of applicant organization.
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-009.html
· 2011 NIDA Translational Avant-Garde Award for Medication Development for Diseases of Addiction (DP1)
(RFA-DA-11-009)
National Institute on Drug Abuse
Application Receipt Date(s): June 27, 2011
http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-009.html
III. Program Announcements
· Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01)
PA-11-026
National Institute on Drug Abuse
Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
http://grants.nih.gov/grants/guide/pa-files/PA-11-026.html
· Functional Genetics, Epigenetics, and Non-coding RNAs in Drug Addiction (R01)
PA-11-033
National Institute on Drug Abuse
Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
http://grants.nih.gov/grants/guide/pa-files/PA-11-033.html
· Functional Genetics, Epigenetics, and Non-coding RNAs in Drug Addiction (R21)
PA-11-034
National Institute on Drug Abuse
Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
http://grants.nih.gov/grants/guide/pa-files/PA-11-034.html
· Functional Genetics, Epigenetics, and Non-coding RNAs in Drug Addiction (R03)
PA-11-035
National Institute on Drug Abuse
Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
http://grants.nih.gov/grants/guide/pa-files/PA-11-035.html
· The Development of Frontal Cortex And Limbic System And Their Roles In Drug Abuse (R01)
PA -11-027
National Institute on Drug Abuse
Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
http://grants.nih.gov/grants/guide/pa-files/PA-11-027.html
IV. Request for Information
· Request for Information (RFI): Creation Of A Consortium-Based Repository Of fMRI-Based Connectivity Brain Scans From Substance-Using Or Abusing Clinical Research Participants
NOT-DA-11-008
National Institute on Drug Abuse
Response Date: March 15, 2010
http://grants.nih.gov/grants/guide/notice-files/NOT-DA-11-008.html
The National Institute on Drug Abuse at the National Institutes of Health is an agency of the United States Department of Health and Human Services
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