I. The RRID: An easy way to make methods sections better.
II. Request for Information (RFI): Challenges and Opportunities for Exploring and Understanding the Epitranscriptome NOT-RM-15-007
NIH Roadmap Initiatives.
III. BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit Specific Processes in the Brain (U01) RFA-MH-15-225
IV. BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01) RFA-NS-15-003
V. BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01) RFA-NS-15-004
VI. 4D Nucleome Imaging Tools (U01) RFA-RM-14-007
VII. Extracellular Vesicles in HIV/AIDS and Substance Abuse (R21) RFA-DA-15-012 and (R01) RFA-DA-15-011
VIII. Prize Competition: Challenges in Single Cell Analysis NOT-RM-14-014
XI. Administrative Supplement for Research on Sex/Gender Differences PA-15-034
I. The RRID: An easy way to make methods sections better.
Arguments about research reproducibility continue (Nature has a special issue on this topic), but nobody would argue that better identification of research resources, the most basic tools of science e.g., antibodies, organisms or software tools, is a bad idea. The RII group (force11.org/node/4463, which includes partners such as J.Neurosci, JCN, etc.) helps authors identify research resources without ambiguity and we would love to throw our support behind this effort. For authors it is as easy as going to http://scicrun.ch/resources, searching for your resource, copying the "cite this" text and pasting it in your methods. The resource reference should look like this: NeuN antibody, Millipore Cat# MAB377, RRID:AB_2298772. If enough people do this, we can ask PubMed Central or google scholar "who is using my antibody and under what conditions?" For the NeuN antibody and common software tools this is possible now, see:
http://scholar.google.com/scholar?q=RRID%3AAB_90755
http://scholar.google.com/scholar?q=RRID%3Anif-0000-30467
http://scholar.google.com/scholar?q=RRID%3Arid_000042
II. Request for Information (RFI): Challenges and Opportunities for Exploring and Understanding the Epitranscriptome (NOT-RM-15-007)
NIH Roadmap Initiatives. Please respond by January 10, 2015
The purpose of this Request for Information (RFI) is to solicit feedback from the community on the scientific challenges, opportunities, and tool/technology needs in the area of RNA chemical modifications (sometimes referred to as epitranscriptomics), with the ultimate goal of accelerating our understanding of the roles of RNA modifications in human health, development and disease.
III. BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit Specific Processes in the Brain (U01) RFA-MH-15-225
Applications due March 18, 2015, by 5:00 PM
The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species / model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.
IV. BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01) RFA-NS-15-003
Application due date: February 10, 2015, by 5:00 PM local time of applicant organization
Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for large scale recording and manipulation of neural activity, to enable transformative understanding of dynamic signaling in the nervous system. In particular we seek exceptionally creative approaches to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high risk, but if successful could profoundly change the course of neuroscience research.
Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Where appropriate, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
V. BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01) RFA-NS-15-004
Application due date: February 10, 2015, by 5:00 PM local time of applicant organization.
Although invention and proof-of-concept testing of new technologies are key components of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. In this FOA we seek applications for thoptimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice.
Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to apply expertise that integrates appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
VI. 4D Nucleome Imaging Tools (U01) RFA-RM-14-007
Application due date: February 2, 2015
The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications that propose to develop and validate physical, chemical and biochemical approaches for measuring properties and dynamics of the three-dimensional organization of the genome that cannot be measured adequately using existing methodologies.
VII. Extracellular Vesicles in HIV/AIDS and Substance Abuse (R21) RFA-DA-15-012 and (R01) RFA-DA-15-011
The purpose of this FOA is to encourage research projects that investigate extracellular vesicles in HIV infection/progression or as potential HIV/AIDS biomarkers or therapeutics. Proposed projects must also explore the potential impact of exposure to substances of abuse.
VIII. Prize Competition: Challenges in Single Cell Analysis NOT-RM-14-014
The NIH Common Fund Single Cell Analysis Program is seeking novel robust methods for analysis of individual cells that can detect and assess changes in cell behavior and function over time either as a result of natural state changes or when perturbed (e.g., by a drug, biological stimulus, infectious agent, pathological lesion, or mechanical forces). It is hoped that such methods will yield creative and new, yet feasible, solutions for following a single cell over time in a complex multicellular environment to detect changing cell properties, preferably using multiple integrated measures.
Please direct all inquiries to:
Yong Yao, Ph.D.
NIH Common Fund
National Institute of Mental Health (NIMH)
Telephone: 301-443-6102
Email: Yong.Yao@nih.gov
XI. "Administrative Supplement for Research on Sex/Gender Differences," PA-15-034 Application Deadline: January 12, 2015 by 5:00 PM local time of applicant organization.
The NIH Office of Research on Women's Health (ORWH) again announces the availability of 1-year administrative supplements up to $100,000 in total costs to support research highlighting the impact of sex/gender differences (or similarities) and/or sex and gender factors in human health and illness, including basic, preclinical, clinical and behavioral studies. Of special interest are studies relevant to understanding of the significance of biological sex on cells; comparative studies of male and female tissues, organ systems and physiological systems; sex based comparisons of pathophysiology, biomarkers, gene expression, clinical presentation and prevention and treatment of diseases. Whereas in FY14 the ORWH set aside was $5 million for 50 supplements, for FY 15
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