2010-12-21

[DIV28SUPER] NIDA Neuroscience Update, December 22, 2010

Table of Contents

I. Proposed Institute for Substance Use, Abuse, & Addiction

 

II. RFA-DA-11-004. Pharmacological Development of Treatment Agents and Formulations for Tobacco Dependence (STTR [R41]) Applications

Receipt date:  January 13, 2011

http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-004.html

 

III. Collaborative Research in Computational Neuroscience (CRCNS) Innovative Approaches to Science and Engineering Research on Brain Function [R01]  http://www.nsf.gov/pubs/2011/nsf11505/nsf11505.htm

Receipt Dates: February 16, 2011, November 2, 2011 and November 2, 2012

 

IV. PAR-11-032 Methods and Approaches for Detection of Gene-Environment Interactions in Human Disease (R21) (http://grants.nih.gov/grants/guide/pa-files/PAR-11-032.html)

Receipt date: February 3, 2011

 

V. PA-11-009 Translational Scholar Career Awards in Pharmacogenomics and Personalized Medicine (K23) (http://grants.nih.gov/grants/guide/pa-files/PA-11-009.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

VI. PA-11-026 Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-026.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

VII. PA-11-033 Functional Genetics, Epigenetics, and Non-coding RNAs in Drug Addiction

(R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-033.html)

(R21) (http://grants.nih.gov/grants/guide/pa-files/PA-11-034.html)

(R03) (http://grants.nih.gov/grants/guide/pa-files/PA-11-035.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

VIII. PA-11-027 The Development of Frontal Cortex and Limbic System and Their Roles in Drug Abuse (R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-027.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

IX.  PA-11-047  Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence

(R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-047.html)

(R21)  (http://grants.nih.gov/grants/guide/pa-files/PA-11-048.html

(R03)  http://grants.nih.gov/grants/guide/pa-files/PA-11-049.html

 

X. RFA: Support Opportunity for Addiction Research (SOAR) for New Investigators (R03)

http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-010.html

Letter of Intent Due Date:  January 3, 2011

Receipt Date: February 2, 2011

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

 

 

I. Proposed Institute for Substance Use, Abuse, & Addiction

On Nov. 15, 2010, the National Institutes of Health (NIH) received the formal recommendation from the Scientific Management Review Board (SMRB) to create a new Institute that would focus on substance use, abuse, and addiction research and related public health initiatives. This proposed Institute would integrate the relevant research portfolios from the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and other NIH Institutes and Centers. The NIH agrees that the proposed realignment of NIH programs into a single, new Institute devoted to such research makes scientific sense and would enhance our efforts to address the substance abuse and addiction problems that take such a terrible toll on our society. For more information go to http://feedback.nih.gov/index.php/category/suaa/.  To submit questions about the proposed merger go to http://feedback.nih.gov/index.php/suaa/suaa-questions/ and to post comments go to http://feedback.nih.gov/index.php/suaa/suaa-comments/

 

II.  RFA-DA-11-004. Pharmacological Development of Treatment Agents and Formulations for Tobacco Dependence (STTR [R41])

Receipt date:  January 13, 2011

http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-004.html

The National Institute on Drug Abuse (NIDA) solicits applications for the development of novel treatments for nicotine dependence.  Up to $1.5M has been set aside to fund 4 or more meritorious small business technology transfer phase I (STTR) 1-year grants in FY2011!  Awardees would subsequently be eligible to apply for Phase II funding. Phase II projects can be supported at a level of ~$1M over two years and be competitively renewed. 

The STTR program ( http://grants.nih.gov/grants/funding/sbirsttr_programs.htm) is designed to fund collaborative projects between small businesses and non-profit research institutions. Its objectives are to move ideas from the laboratory into the marketplace and foster high-tech economic development. Because NIDA recognizes the potential complexity of establishing business-academic collaborations, NIDA staff will help cultivate these relationships for potential applicants.  

 

III. Collaborative Research in Computational Neuroscience (CRCNS) Innovative Approaches to Science and Engineering Research on Brain Function [R01]  http://www.nsf.gov/pubs/2011/nsf11505/nsf11505.htm

Receipt Dates: February 16, 2011, November 2, 2011 and November 2, 2012

 

The Collaborative Research in Computational Neuroscience (CRCNS) research grant initiative has just been re-issued from seven National Science Foundation (NSF) Directorates and Offices (DOs), and nine participating National Institutes of Health (NIH) Institutes and Centers (ICs) including NIDA.  The German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF http://www.bmbf.de/) is a formal partner and CRCNS is also affiliated with the NIH Blueprint for Neuroscience Research (http://neuroscienceblueprint.nih.gov). 

Through the CRCNS program, participating NSF DOs, NIH ICs and BMBF support innovative interdisciplinary collaborative research to make significant advances in the understanding of structures and functions of the nervous system, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.  Three general perspectives for proposals will be considered in response to this solicitation:

Research proposals - describing new collaborative research projects

US-German Research Proposals - describing international collaborative research projects to be funded in parallel by US and German agencies

Data Sharing Proposals - enable sharing of data and other resources

The CRCNS announcement is released under NSF 11-505. For more details including how to apply and for program contacts please go to the full announcement: http://www.nsf.gov/pubs/2011/nsf11505/nsf11505.htm

 

IV. PAR-11-032 Methods and Approaches for Detection of Gene-Environment Interactions in Human Disease (R21) (http://grants.nih.gov/grants/guide/pa-files/PAR-11-032.html)

Receipt date: February 3, 2011

 

This FOA issued by NIEHS, National Institutes of Health, encourages grant applications from institutions/organizations to develop and test innovative statistical and bioinformatics methods and analytical strategies and study designs for identifying gene-environment interactions for complex human diseases.  The objectives of this FOA are to further advance the understanding of gene-environment interplay in complex human disease by 1) the development and validation of algorithms and new statistical and computational approaches and study designs and/or 2) the development and application of bioinformatics software for gene-environment analysis of existing human populations.   

 

V. PA-11-009 Translational Scholar Career Awards in Pharmacogenomics and Personalized Medicine (K23)(http://grants.nih.gov/grants/guide/pa-files/PA-11-009.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

The purpose of this Mentored Patient-Oriented Research Career Development Award (K23) is to provide salary and “protected time” (up to five years for this award) to support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research.  Each Research Career Development Award must be tailored to meet the individual needs of the candidate.  The Translational Scholar Awards in Pharmacogenomics and Personalized Medicine program is intended to address the scarcity of investigators cross-trained in both clinical research core competencies and modern methods required to address pharmacogenomics research problems in patient populations.  Dual mentors from the Clinical and Translational Science Awards consortium and the Pharmacogenomics Research Network are required.

 

VI. PA-11-026 Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-026.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

This FOA encourages applications for research projects that identify and/or validate chromosomal loci and variations in genes that are associated with vulnerability to addiction and that inform the likelihood of responsiveness to treatment.  Applications that propose to examine intermediate phenotypes or endophenotypes to assess the molecular genetics of drug addiction, addiction vulnerability and/or their associated co-morbidities and how they are related to drug addiction are especially encouraged.  Also encouraged are genetic as well as computational and large-scale genomic approaches, which may include but are not limited to linkage, linkage disequilibrium, case-control or family-based studies, and integration of data from other databases that may supplement substance abuse genetics and genomics data.  Data may be collected from the general population, special populations, recent admixed populations, and/or animal models.  Investigators are encouraged to include, as a component of their project and as appropriate, gene x gene interactions, gene x environment interactions, gene x environment x development interactions, pharmacogenetics, and non-human models.

 

VII. PA-11-033 Functional Genetics, Epigenetics, and Non-coding RNAs in Drug Addiction

(R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-033.html)

(R21) (http://grants.nih.gov/grants/guide/pa-files/PA-11-034.html)

(R03) (http://grants.nih.gov/grants/guide/pa-files/PA-11-035.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

Purpose Genetic and genomic studies have identified genes and gene variants that potentially modulate the fundamental biological mechanisms underpinning addictive processes.  Discovery of these genes/variants, while extremely valuable, is only a first step in understanding molecular mechanisms of addiction.  This Funding Opportunity Announcement encourages basic functional genomic research in two areas:  1. functional validation to determine which candidate genes/variants/epigenetic/non-coding RNA features have an authentic role in addictive processes, and 2. detailed elucidation of the molecular pathways and processes modulated by candidate genes/variants, particularly for those genes with an unanticipated role in addiction.

 

VIII. PA-11-027 The Development of Frontal Cortex and Limbic System and Their Roles in Drug Abuse (R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-027.html)

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

This Funding Opportunity Announcement (FOA) issued by NIDA encourages Research Project Grant (R01) applications from institutions/organizations that propose to study the development of the frontal and prefrontal cortices, together with the subcortical areas of the limbic system, that play significant roles in mediating emotional and motivated behavior.  This initiative is designed to support the basic neuroscience research into the fundamental mechanisms of development of the frontal and prefrontal cortices, as well as the midbrain and basal forebrain structures that mediate a number of functions related to drug abuse and psychiatric disorders including:  the euphoric properties of drugs, actions of psychotherapeutic agents, and memory, cognitive and emotional functions.  An additional major goal of this initiative is to understand how exposure to drugs of abuse affects the cellular and molecular mechanisms underlying nervous system development of circuits implicated in drug reward and addiction. 

 

IX.  PA-11-047  Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence

(R01) (http://grants.nih.gov/grants/guide/pa-files/PA-11-047.html)

(R21)  (http://grants.nih.gov/grants/guide/pa-files/PA-11-048.html

(R03)  http://grants.nih.gov/grants/guide/pa-files/PA-11-049.html

Receipt dates: Standard dates apply http://grants1.nih.gov/grants/funding/submissionschedule.htm 

 

The purpose of this Funding Opportunity Announcement (FOA) issued by the National Institute on Drug Abuse (NIDA) and National Institute on Alcohol Abuse and Alcoholism (NIAAA) is to advance research on male-female differences in drug and alcohol abuse and addiction and on factors specific to women.  Both human research and animal model studies are sought.   

 

X. RFA: Support Opportunity for Addiction Research (SOAR) for New Investigators (R03)

http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-010.html

Letter of Intent Due Date:  January 3, 2011

Receipt Date: February 2, 2011

 

The National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) are interested in receiving applications to supplement new investigators who have, or have a commitment of support to conduct research in basic or clinical alcohol or drug abuse research from funding sources other than NIH (e.g. private foundation).  In addition, those applicants currently supported to conduct research on psychiatric disorders that are often found to be co-morbid with substance abuse, are also eligible to apply to SOAR for the purpose of adding a substance or alcohol abuse research component to their on-going research.  It is hoped that the SOAR program will facilitate ongoing supported substance abuse and co-morbidity research among entry-level new investigators.  This Funding Opportunity Announcement (FOA) is intended to support new investigators’ on-going basic or clinical alcohol, drug abuse and/or related co-morbidity research. The primary goal of this Support Opportunity for Addiction Research (SOAR) is for new investigators to leverage existing research programs in order to strengthen, possibly expand, and/or further develop alcohol, drug abuse, and co-morbidity research.   For more details see: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-010.html

   

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